the effect of enoxaparin and clopidogrel on survival of random skin flap in rat animal model

نویسندگان

mohammad javad fatemi associate professor of department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran.

kamal s forootan associate professor of department of plastic surgery, burn research center, hazrate fatemeh hospital, tehran university of medical sciences, tehran, iran

seyed ziaaddin s jalali plastic surgeon, vali asr police hospital, tehran, iran.

seyed jaber mousavi department of community medicine, burn research center, tehran university of medical sciences, tehran, iran.

چکیده

background necrosis of skin flaps is considered as an important complication in reconstructive surgery. we conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. methods forty male, adult sprague-dawlay rats were divided randomly into 4 groups. standard rectangular, distally based dorsal random pattern skin flap was elevated. to prevent the graft effect, a sterile sheet was put under the flap. no pharmacological agent was administered for the control group. in group 2, single subcutaneous dose of enoxaparin (3.2 mg/kg) was immediately administrated after surgery. in group 3, clopidogrel (25 mg/kg) was given orally for 7 days. in group 4, both enoxaparin and clopidogrel were administrated. the rats were evaluated on post-operative day 7 for viable and necrotic portions of flaps. results the mean and sd of necrosis was 17.79+2.5 cm in the control group, 16.20±3.1 cm in low-molecular weight heparin, 15.25+3.8 cm in combined therapy group and 13.69+2.7 cm in clopidogrel group. clopidogrel was the only pharmaceutical agent that produced a significant increase in the flap survival area. conclusion clopidogrel may be an effective pharmaceutical agent that significantly increases viability of random skin flaps in rats, but low-molecular weight heparin and their combination did not have any significant beneficial effects.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Enoxaparin and Clopidogrel on Survival of Random Skin Flap in Rat Animal Model

BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal ran...

متن کامل

The Effect of Enoxaparin and Clopidogrel on Survival of Random Skin Flap in Rat Animal Model

BACKGROUND Necrosis of skin flaps is considered as an important complication in reconstructive surgery. We conducted an experimental study to investigate the efficacy of low-molecular weight heparin, clopidogrel and their combination to improve the flap survival. METHODS Forty male, adult Sprague-Dawlay rats were divided randomly into 4 groups. Standard rectangular, distally based dorsal rand...

متن کامل

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

Comparison of effect of botulinum toxin with clopidogrel and concomitant prescription of them in the survival of random skin flap in rats

Introduction: In this study, the effect of botulinum toxin A and clopidogrel and concomitant administration of them in the survival of random skin flap in rat model were studied. Correspondence: Ghasemali. Khorasani, MD. Surgery Department, Immam Khomeini Hospital Complex, Tehran University of Medical Sciences. ...

متن کامل

the effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)

cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
world journal of plastic surgery

جلد ۱، شماره ۲، صفحات ۶۴-۷۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023